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Hosted by Mark Mattson · EN-US · 221 episodes
Established thought leaders with verified media credentials.
Conversations with neuroscientists, neurologists, evolutionary biologists, anthropologists, computer scientists, and others that ponder the brain. Here are a few of the questions that BRAIN PONDERINGS will tackle:How have brains evolved to enable success in diverse environments?How does the brain develop in the womb and in early life?What are the mechanisms responsible for learning and memory, language, and emotions?How does the brain respond to life's challenges?In what ways does the brain influence the body and vice-versa?What is known about the causes of psychiatric, neurodegenerative, and other brain disorders?What new technologies are being developed to treat neurological disorders?How do naturally occurring and man-made chemicals affect the brain?How can gene therapy, cell regeneration, and brain stimulation be used for brain disorders?What are the boundaries between ethical and unethical neuroscience research?
Mark Mattson hosts Brain Ponderings podcast with Dr. Mark Mattson, a science show with 221 episodes published.
The molecular machinery that translates the messenger RNAs into protein is located in ribosomes. Ribosomes are present within neurons in or near synapses, where they are particularly abundant in postsynaptic sites. Evide
With the advent of new technological approaches and emerging discoveries has come a growing appreciation for the importance of astrocytes in neuroplasticity. In contrast to the chemical synapses between neurons, astrocyt
The roundworm C. Elegans has proven to be a valuable organism for advancing understanding of fundamental molecular and cellular mechanisms of aging because of its short lifespan, ease of genetic manipulations, and fully
Astrocytes are known to play important roles in brain energy metabolism and the regulation of neuronal network activities. A single astrocyte has a highly elaborate and expansive morphology which enables it to interact w
The disease process in Alzheimer's disease involves local inflammatory processes wherein microglia are activated and produce pro-inflammatory cytokines. Accumulations of amyloid beta-peptide promote neuroinflammation by
While it has long been known that activity in neural networks in sleep differs from activity during waking hours. EEG recordings have revealed patterns of activity oscillations associated with deep (non-REM) sleep and ra
In this episode I talk with Weill Cornell Medicine professor Tim Ryan about the local regulation of energy metabolism in synapses. Tim and his colleagues use high resolution imaging of fluorescent probes that enable meas
In Alzheimer's disease and other 'Tauopathies' the Tau protein (which normally controls the polymerization of microtubules) becomes hyperphosphorylated and self-aggregates into insoluble fibrils called 'neurofibrillary t
Ultraprocessed foods that contain high amounts of simple sugars (particularly high-fructose corn syrup), saturated fats, salt, and various chemicals that enhance taste and color. In this episode I talk with University of
In this episode – a role reversal. Mark is interviewed by Justin Lathia a professor at the Cleveland Clinic and former graduate student in Mark's lab. The podcast provides a whirlwind tour of Mark's early life and resear
The combined efforts of neurologists, geneticists, molecular biologists, and electrophysiologists have identified genes in which rare mutations cause either extreme pain sensitivity or complete lack of pain sensation. Th
Optimal health depends critically on maintenance of an evolutionarily ancient circadian clock that ticks within all cells of the body and brain. Discovery of the genes that encode the core proteins of the molecular clock
In this episode I talk with MIT neuroscientist Ev Fedorenko about the neural networks that process language in the human brain, the relationships between the processing of language and thought, evolutionary perspectives
Vision loss is a major cause of disability throughout the world. While there are effective treatments for cataracts and for preventing glaucoma, there are numerous genetic disorders that cause degeneration of cells in th
It is well-established that neurons have a high energy (ATP) demand and that mitochondrial impairment can render neurons vulnerable to degeneration. However, surprisingly little is known about the involvement of mitochon
How does the brain rapidly integrate information coming our different senses with stored information, and their saliences, so as to make decisions and respond (or not)? In this episode I talk with UCLA Professor Lucina U
The amyloid precursor protein (APP) is a transmembrane protein and the source of the amyloid beta-peptide that accumulates in plaques in the brain in Alzheimer's disease. However, the normal function(s) of APP are uncert
There are about 100 billion neurons and 100 trillion synaptic connections between them in the human brain. The activity of those neural networks is controlled by only a handful of major neurotransmitters and all neurons
Distributed throughout the brain are oligodendrocyte precursor cells (OPCs) capable of proliferating and differentiating into the oligodendrocytes that wrap around axons (myelination) thereby greatly increasing signal pr
How do neural networks in the cerebral cortex transform incoming sensory information to generate perceptions of the world and elicit behavioral responses? This question is being tackled in the laboratory UC Berkeley Prof
Thomas Hartung
Professor of Pharmacology and Toxicology · Johns Hopkins University
1 appearance on this show
Jason Shepherd
Assistant Principal · Shep’s Cards
1 appearance on this show
Daniel Schacter
professor and past chair of psychology · Cosmetic Physician Partners
1 appearance on this show
David Nutt
Professor of neuropsychopharmacology · Imperial College London
1 appearance on this show
Richard Petty
Dr.
1 appearance on this show
Amit Bar-Or
MD, FRCPC, FAAN, FANA · University of Pennsylvania
1 appearance on this show
Kevin Tracey
Neurosurgeon and Author of The Great Nerve · Feinstein Institutes for Medical Research
1 appearance on this show
Alan Watts
The Love Engineer · The Love Engineer
1 appearance on this show
Dr. Christof Koch
Chief Scientist of the MindScope Program · Allen Institute for Brain Science
1 appearance on this show
Satchin Panda
Professor · Regulatory Biology Laboratory at the Salk Institute for Biological Studies
1 appearance on this show
Eric Klann
New York University
1 appearance on this show
Scott Leiser
University of Michigan
1 appearance on this show
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Brain Ponderings podcast with Dr. Mark Mattson is hosted by Mark Mattson. The show is categorised under science (natural) and has published 221 episodes.
Brain Ponderings podcast with Dr. Mark Mattson has published 221 episodes.
Brain Ponderings podcast with Dr. Mark Mattson regularly covers science, natural, health. It sits in the science category, with a natural focus.
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Episodes of Brain Ponderings podcast with Dr. Mark Mattson average 69 minutes, giving guests a long-form format with plenty of time to expand on their expertise.
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