Decoding Longevity

A podcast dedicated to unraveling the mysteries of aging through the lens of cutting-edge science. Each episode breaks down the latest research papers in the field of geroscience, offering clear, insightful discussions on longevity, biological aging, and the quest for extending healthspan. Perfect for scientists, enthusiasts, and anyone curious about the science behind living longer and healthier lives.

Decoding Longevity is a health podcast hosted by Raghav Sehgal, with 33 episodes on record and a Required Pod Score of 80. PitchCentric scores this show on Booking Probability, Listen Score, and live audience signals refreshed every 24 hours.

Raghav Sehgal hosts Decoding Longevity, a health show with 33 episodes published.

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  Episode #34

  Is Rapamycin Dead? — A Conversation with Matt Kaeberlein

  Sep 16, 202654 min

  What if we could slow biological aging itself—not just treat the diseases that come with it? In Episode 34 of Decoding Longevity , Raghav Sehgal and Dr. Macsue Jacques sit down with Professor Matt Kaeberlein to explore the biology of aging and what it might mean to actually intervene in the aging process. They discuss mTOR and rapamycin, the debate around rapamycin in humans, and why Matt believes some recent evidence has been misunderstood. The conversation also covers the Dog Aging Project, the TRIAD trial, Aura Biomedical, AI-powered lifespan research, and the future of longevity biotech. From yeast and worms to dogs and humans, this episode explores how we can move from understanding aging to potentially changing it.

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  Episode #33

  Can a Shingles Vaccine Slow Down Dementia? Survival, Cognitive Preservation, and Immune Modulation

  Sep 4, 202631 minS1

  Could a shingles vaccine also influence dementia? In Episode 33 of Decoding Longevity, Dr. Raghav Sehgal and Dr. Macsue Jacques are joined by Dr. Moshe Shay Ben-Haim to explore his team’s findings linking the Shingrix vaccine with improved survival and cognitive preservation in people living with dementia. They discuss trained immunity, latent viruses, epigenetics, and what this surprising connection could mean for the future of neurodegeneration and longevity research. Importantly, the findings are observational and do not establish Shingrix as a treatment for dementia.

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  Episode #31

  Moving Beyond Mortality Clocks: Responsive Rate of Aging Biomarkers with Associate Professor Dan Belsky

  Aug 5, 202647 min

  Can two people of the same age be aging at completely different speeds? In this episode, Dr. Raghav Sehgal and Dr. Macsue Jacques speak with Associate Professor Daniel W. Belsky about the science behind DunedinPACE and why measuring the pace of aging may be more valuable than estimating biological age. The conversation covers the Dunedin Study, aging biomarkers, the CALERIE trial, and the ARPA-H FAST Initiative—offering a look at how researchers are building the next generation of tools to evaluate longevity interventions. Follow Decoding Longevity for more conversations with leading researchers shaping the future of healthy aging.

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  Episode #30

  Testing the Longevity Promise: What Mice Can Really Teach Us About Slowing Ageing — A Conversation with Professor Richard Miller

  Jul 22, 202648 min

  Can we really slow biological aging? In this episode of Decoding Longevity , Professor Richard A. Miller—Professor of Pathology at the University of Michigan and a founding leader of the National Institute on Aging's Interventions Testing Program (ITP) —joins us to explore how scientists determine whether a longevity intervention truly works. From rapamycin and acarbose to biomarkers, healthspan, and the challenges of translating mouse studies into human medicine, this conversation examines what decades of rigorous research reveal about slowing aging—and why evidence matters more than hype.

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  Episode #29

  Longevity for Everyone: HIV, Prevention, and the Future of Global Healthy Aging — A Conversation with Professor Linda-Gail Bekker

  Jul 1, 202631 min

  What if the greatest breakthrough in longevity isn't slowing aging—but preventing disease before it begins? In this episode of Decoding Longevity , we speak with Professor Linda-Gail Bekker , one of the world's leading experts in HIV prevention, tuberculosis research, and global public health. Together, we explore how HIV research has transformed our understanding of longevity, from restoring life expectancy through antiretroviral therapy to preventing infection with groundbreaking advances like Lenacapavir . We discuss healthspan versus lifespan, chronic inflammation, accelerated biological aging, health equity, and why prevention may be the most powerful longevity intervention of all. This conversation offers a compelling look at how advances in infectious disease research are shaping the future of healthy aging.

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