health
Hosted by Sabin Subedi · health · EN
Step into the forefront of abdominal transplant surgery — where innovation meets ongoing complexity. Machine perfusion and normothermic regional perfusion (NRP) are reshaping organ preservation and donor utilization, with growing evidence that these technologies improve graft assessment and early outcomes. Yet reviews continue to highlight key challenges — ischemia–reperfusion injury, biliary complications in DCD grafts, and the logistical demands of perfusion platforms. Despite these hurdles, transplantation is shifting from an urgent, unpredictable field toward a planned, daytime specialty. The next horizon, underscored by recent expert reviews, is true organ banking — bringing us closer to on-demand, schedulable transplantation.
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Signup to Generate a PitchStep into the forefront of abdominal transplant surgery, where innovation meets ongoing complexity. Machine perfusion and normothermic regional perfusion (NRP) are reshaping organ preservation and donor utilization, with growing evidence that these technologies improve graft assessment and early outcomes.
Trenches in Transplant Surgery is hosted by Sabin Subedi. The show has published 46 episodes to date.
Recent episodes include "The Cr is 6.4. Would you accept this kidney?" (30 October 2026, 24 minutes), "AI Transplant Agents: Autonomy and Accountability" (24 October 2026, 31 minutes), and "Too Sick to Transplant?" (14 October 2026, 39 minutes).
Trenches in Transplant Surgery publishes roughly a few times a week, with episodes averaging 41 minutes across 46 episodes.
Booking probability for Trenches in Transplant Surgery is 25%, and the host is rated Selective on guests. Trenches in Transplant Surgery requires a Pod Score of 80 or higher. Trenches in Transplant Surgery's contact route on record: verified email.
The strongest fits for Trenches in Transplant Surgery are Hospitals and Health & Wellness Services. Trenches in Transplant Surgery has a health audience.
Sabin Subedi hosts Trenches in Transplant Surgery, a health podcast with 46 episodes published.
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Episode #13
A clinical case study addressing whether to accept a high-risk kidney from a donor with severe acute kidney injury and dialysis dependence. Through this scenario, the text emphasizes that donor dialysis does not...
This episode examines the integration and ethical implications of artificial intelligence in healthcare , focusing heavily on organ transplantation and patient referral processing. Platforms like Afflo utilize real-time...
Episode #11
Acute-on-chronic liver failure is a critical medical syndrome characterized by the acute deterioration of chronic liver disease, resulting in severe organ failures and high short-term mortality. The condition is...
Episode #10
Liver transplantation for hepatocellular carcinoma (HCC) requires balancing tumor biology, medical urgency, and waitlist equity, as standard Model for End-Stage Liver Disease (MELD) scores often fail to capture cancer...
Episode #9
This episode examines the critical oversight in liver transplantation literature where the broad label of normothermic machine perfusion (NMP) is used to describe fundamentally different preservation workflows. They...
This episode emphasizes that liver transplantation is often preceded by years of progressive disease that can sometimes be intercepted through proactive clinical intervention. While an initial diagnosis does not...
Islet transplantation represents a promising approach to restoring insulin production, though achieving a comprehensive solution requires overcoming significant hurdles related to cell supply, engraftment, and immune...
The complement system is emerging as a major determinant of kidney transplant injury, rejection, and recovery. Rather than acting only as a terminal lytic pathway, complement connects innate and adaptive immunity and...
Episode #4
Edit the Disease - or Replace the Liver? examines whether mRNA therapy, gene replacement, CRISPR and base editing could eventually prevent the need for liver transplantation. Human studies already show that therapeutic...
This episode makes the case that abdominal organ procurement—especially DBD recovery—is one of the most underused training environments for major abdominal surgery . The central argument is that procurement should not...
Episode #2
The Number on the Offer: Rethinking the Liver Donor Risk Index The liver donor risk index helped transplant teams quantify donor-associated graft risk. But an organ-offer decision requires more than a score: it depends...
Episode #9
This episode examines the critical oversight in liver transplantation literature where the broad label of normothermic machine perfusion (NMP) is used to describe fundamentally different preservation workflows. They...
This episode explores the critical role of **lactate metabolism** as a biomarker for assessing organ quality in **Donation after Circulatory Death (DCD)** compared to **Donation after Brain Death (DBD)**. While the...
By 2050, organ transplantation will be radically transformed—from a scarce, donor-dependent therapy into a diverse ecosystem of biological and technological solutions. Patients will receive organs from genetically...
Regulatory T cells (Tregs)—discovered by Shimon Sakaguchi, Mary Brunkow, and Fred Ramsdell, who were awarded the 2025 Nobel Prize—are central to inducing immune tolerance and preventing organ transplant rejection. These...
Desensitization has transformed kidney transplantation for patients with high immunologic risk by lowering or removing antibodies that would otherwise cause graft loss. Pre- and peri-transplant plasmapheresis...
When a deceased-donor offer arrives, the on-call surgeon rapidly weighs donor organ quality, recipient need, and logistics within OPTN/UNOS policy. For kidneys, decisions hinge on KDPI, creatinine/AKI course...
Chimerism—the coexistence of donor and recipient hematopoietic cells—has become central to understanding and inducing immune tolerance in solid organ transplantation. Early work by Owen, Medawar, and later Starzl...
Following a recent New York Times report that questioned the ethics and safety of donation after circulatory death (DCD) , this episode clarifies how DCD and donation after brain death (DBD) actually work in U.S. organ...
During normothermic machine perfusion (NMP), several red flags may prompt declining a liver for transplantation. The most critical biochemical warning is failure to clear lactate to 6000 IU/L) reflect ongoing...
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