
Tone It Down
Be the CEO of Your Own Health: Ways2Well CCO Danese Rexroad on Labs, HRT & Longevity
This week on Tone It Down, Karena sits down with Danese Rexroad, the OG Chief Clinical Officer at Ways2Well, a Texas-based preventative healthcare company. Danese spent 15 years in trauma and the ER before moving into preventative wellness, and one night in the trauma unit changed how she sees everything: your baseline health shapes your outcome. She explains the difference between "normal" and "optimal" blood work, which hormones shift first in perimenopause, and why so many women get handed an antidepressant when it’s really something else that’s missing. They get into peptides, the truth about testosterone for women, GLP-1s as a bridge rather than a quick fix, and the brand-new world of Muse cells. [03:03] Normal vs. Optimal: What Your Blood Work Is Really Telling You "Normal" ranges cover the entire population. Optimal ranges are much narrower and catch issues before they become problems. Symptoms matter as much as numbers. If you feel off and your labs look fine, keep asking questions. A standard GP panel often skips progesterone, testosterone, free testosterone, DHEA, insulin, and full thyroid markers. [16:57] Menopause Is a Journey, Not a Destination Symptoms to watch for: insomnia, new joint aches, frozen shoulder, vaginal dryness, vision changes, brain fog, and stubborn belly fat. Danese's own first symptom was a frozen shoulder, a year before her labs showed a change. Rising insulin resistance and cortisol both play a role in midlife weight gain. [23:15] Sleep, Bedtimes & Melatonin Setting a consistent bedtime supports your circadian rhythm, gut, mood, and hormones. Melatonin can work as a short-term bridge, but the bigger question is why your body isn't making enough. Check your sleep environment first: room temperature, pillow, air quality, and a snoring partner all count. [34:43] Peptides 101 Think of a peptide like a text message: a short instruction that tells your body what to repair. Danese breaks down her favorites, including BPC-157 for tissue repair, GHK-Cu (copper peptide) for skin and inflammation, and thymosin alpha for autoimmune support. Why sourcing matters: untested "gray market" peptides bought online may not contain what the label says. [48:55] Muse Cells & Regenerative Medicine Muse cells are a rare subset of stem cells that can travel to damaged tissue and help repair it. Danese uses them for injuries, joints, and whole-body recovery. She explains why lab standards and limited replication matter for quality. [59:08] Inside the Longevity Lab & Rapid Fire Danese walks through red light therapy, plasmapheresis, and the HOCATT, her favorite 10-in-1 treatment. Sauna or cold plunge? Danese picks sauna and explains her concerns about cold plunging in perimenopause. Karena shares why the plunge works for her. Strength training over cardio. Magnesium over melatonin. Blood work over the scale. New to the Tone It Up app? Head to toneitup.com/activate and enter code TID20 to take 20% off your annual membership! Connect with Danese: Ways2Well (https://ways2well.com) @daneserexroad on IG (https://www.instagram.com/daneserexroad/) Let's Connect: Karena Dawn — @karenadawn on IG (https://www.instagram.com/karenadawn/) THE BIG SILENCE PODCAST (https://podcasts.apple.com/us/podcast/the-big-silence/id1607181597) Join the #1 Fitness App for Women: Tone It Up App (https://my.toneitup.com/pages/tone-it-up-app) Tone It Up YouTube (https://www.youtube.com/@toneitup/featured) Tone It Up Instagram (https://www.instagram.com/toneitup/?hl=en)

