The Pauling Principle

<p>Designing functional RNA for therapeutics is notoriously hard, but gRNAde changes the game. This geometric deep learning model generates high quality RNA sequences from target 3D structures. It outperforms Rosetta...

<p>What if aging itself is the disease we should be curing? In this episode, I sit down with Aubrey de Grey, the legendary biogerontologist who has spent decades arguing that aging is not an inevitable fate but an...

<p>Antibody design is one of the most exciting challenges in AI drug discovery. After Alphafold solved many of the problems of protein structure prediction, researchers moved their attention to protein structure design...

<p>In this episode, I sit down with Dr. Maria Marinova to uncover one of the most misunderstood frontiers in human biology: female reproductive aging. We break down why female fertility declines, what’s actually...

<p>Matt Kaeberlein is one of the world’s leading scientists in aging biology. He is a biogerontologist with 250+ publications, former University of Washington professor, and co-founder of landmark initiatives like the...

<p>Is protein folding solved? Not quite, even though the progress has been tremendous since the first AlphaFold and up to last year's Nobel prize. The team behind Boltz and Boltz-2, from MIT CSAIL and Jameel Clinic...

<p>Shantanu Singh is one of the principal investigators at the celebrated Broad Institute of MIT and Harvard. His research is centered around finding “fingerprints” of genes, chemicals and diseases from microscopy...

<p>Andy and his team at Vincere have been doing amazing work over years to figure out the mitochondrial mechanisms that may contribute to Parkinson's and other neurodegenerative diseases. Listen in as we discuss curing...

<p>Andrew White and his team at Future House have one of the most ambitious missions. I'll quote here because I couldn't say it better myself: Our mission is to build an AI scientist, or AI systems, that can automate...

<p>What if the biggest breakthroughs in health and biotechnology aren’t waiting on new ideas but on better experiments? In this episode, Michael Florea joins Javier to expose the hidden bottlenecks in animal research...

<p>Join my conversation with Matthew "Oki" O'Connor Co-CEO of Cyclarity Therapeutics. We talk about curing cardiovascular disease, radically extending healthy longevity and the drug discovery journey.</p>

<p>Nicholas Runcie of Oxford University and I discuss whether large language models such as ChatGPT can really understand chemistry. Which of course will be essential as we try to use them to find new medicines and...

<p>Eva Smorodina, researcher at the University of Oslo and expert in Computational Chemistry, joins me for an interesting conversation about designing antibodies, tools for biology and the future of AI and drug...

<p>In this episode I talk with the amazing Reason and Mourad from Repair Bio about a cure for cardiovascular disease. Reason serves as CEO and is also a legend in the world of longevity, having run...

<p>Google recently announced AI Co-Scientist, a state-of-the-art AI agent turbo-charging research. The Co-Scientist team has already uncovered new liver-fibrosis targets and repurposed drugs for cancer. Don't miss this...