
Episode #39
The Gut–Bone Axis: How Gut Health Impacts Bone Health, Calcium Absorption & Osteoporosis (with guest Dr. Laura McCabe)
Your bones aren’t stones, and osteoporosis isn’t just a calcium problem. Bone is living tissue that continuously remodels, and the signals that guide that process may start in an unexpected place: your gut. We dig into the gut–bone axis and the emerging field of osteomicrobiology with Dr. Laura McCabe. We discuss: • How bones are living tissue that continuously remodels • Osteoporosis as a common silent disease—and why fractures are often the first sign. • Osteomicrobiology and how the gut–bone axis may influence inflammation, immune signaling, and hormones • Fiber fermentation and short-chain fatty acids that may support calcium absorption and gut barrier health • The gut microbiome, vitamin K, and its role in bone mineralization • Prunes as a whole-food intervention and the evidence behind six prunes per day • Fermented foods like yogurt and kefir, plus the importance of protein for muscle and bone health • Menopause, estrogen loss, changes in the gut barrier, and inflammation linked to accelerated bone loss • Calcium from food first, caution with high-dose supplements, and practical dairy options including lactose-free choices • Weight-bearing exercise, strength training, and yoga as bone-loading signals and how exercise may also affect the microbiome • Why people respond differently based on genetics, lifestyle, medications, and steroid exposure • Where the science is heading, from metabolomics to more personalized nutrition approaches We hope you’ll share this episode and help spread the word about bone health! This episode was sponsored by Activia. References: De Martinis M, Sirufo MM, Polsinelli M, Placidi G, Di Silvestre D, Ginaldi L. Gender Differences in Osteoporosis: A Single-Center Observational Study. World J Mens Health. 2021 Oct;39(4):750-759. De Souza MJ, Strock NCA, Williams NI, Lee H, Koltun KJ, Rogers C, Ferruzzi MG, Nakatsu CH, Weaver C. Prunes preserve hip bone mineral density in a 12-month randomized controlled trial in postmenopausal women: the Prune Study. Am J Clin Nutr. 2022 Oct 6;11 McCabe LR, Irwin R, Schaefer L, Britton RA. Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice. J Cell Physiol. 2013 Aug;228(8):1793-8. Pang Y, Chen Z, Ju Y, Yang B, Hou J, Zheng S, Li Z, Liu T, Xia H, Xia M, Zhong Y, Li J, Li Z, Jiang X. Association between dietary fiber intake and bone mineral density: a systematic review and meta-analysis of observational studies. Eur J Nutr. 2026 Feb Learn more about our guest, Laura McCabe, PhD Don’t forget to subscribe, rate, and leave us a comment. You can also follow us on social media @TheGutHealthPodcast, where we’d love for you to share your thoughts, questions, and experiences. Learn more about Kate and Dr. Riehl: Website: www.katescarlata.com and www.drriehl.com Instagram: @katescarlata @drriehl and @theguthealthpodcast Order Kate and Dr. Riehl's book, Mind Your Gut: The Science-Based, Whole-body Guide to Living Well with IBS . The information included in this podcast is not a substitute for professional medical advice, examination, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider before starting any new treatment or making changes to existing treatment.

