Podovirus

Rebekah Dedrick shares her background in phage research and her transition to the Cystic Fibrosis (CF) Foundation. She explains how her work with mycobacteriophages intersected with clinical applications, particularly...

<p>What if you could build biology in a tube, no cells required? Invitris is a Munich-based cell-free synthesis company starting with bacteriophages. Kilian Vogele, co-founder of Invitris, joins Jessica and Joe to...

<p>“The thing everybody thinks is a tailwind for our space — the low financial barrier to get into a clinical trial — is actually one of the largest headwinds.”</p><p><br></p><p>Paul has spent 35 years in biopharma, and...

<p>Chip Schooley (UC San Diego, IPATH) and Graham Hatfull (University of Pittsburgh) join us to discuss why phage therapy needs biologists and clinicians collaborating — and what the HIV field’s playbook can teach...

<p>What does it take to build a phage therapy program from nothing — and keep your research lab running at the same time?</p><p><br></p><p>In this episode, Joe and I sat down with Dr. Daria Van Tyne, PhD, Associate...

<p>Can AI design living organisms from scratch? Samuel King and Claudia Driscoll from the Arc Institute used genome language models to generate functional phages—and 16 of them actually worked in the lab. Not only that...

<p>"When I first started, I was treating anything and everything in terms of ‘this is highly drug resistant and it's failed’. But I think I have a clearer idea now, at least clinically, where I think phage would be...

<p>"It's unacceptable to just tell this poor patient, there's nothing I can do to help you... That's when I thought, okay, well, what about kind of pushing the boundaries a bit here and thinking about phage therapy?"...

<p>"Phages are not drugs. Every time they say, 'Did you go through regulatory?' I say, 'I can do regulatory, but I'm not a drug.' There's 145 components of the regulatory requirements that I don't fit in."</p><p><br...

<p>"This feels just like the early days of the HIV crisis. People are dying, you're not hearing about it. We need a group like ACT UP to bring this to the public. We're not going to get phage therapy until people start...

<p>"Finally, finally we have Phase 2 data. We put a dent in the theory that phage therapy doesn't work. Maybe it does work. Maybe it's worth taking a risk."</p><p><br></p><p>Jonathan Solomon joins Jessica Sacher and Joe...

<p>"I was so biased. I knew too much and that's why we couldn't see the obvious answer that was right in front of us for years."</p><p><br></p><p>In this episode of the Podovirus Podcast, we explore the intersection of...

<p>“Getting our foot through the door to any VC... As soon as they hear we're infectious disease, their eyes kind of get big. And then they hear we're antibacterial, their eyes get bigger. And then they hear we're not...

<p>"Somebody's father, friend, husband just passed away in the most developed country in the world... from a simple infection that probably could have been treated in Georgia."</p> <p><br /></p> <p>In this episode, we...

<p>What's it like to be a doctor treating patients with phage therapy in the US today?</p> <p><br /></p> <p>Dr. Gina Suh, Mayo Clinic infectious disease physician, tells us:</p> <p>- How she established phage therapy as...