拆药笔记
001 氯丙嗪：没有 RCT 的年代，一个药怎么证明自己有效？
Jul 3, 202618 minS0
1951 年，一个法国外科医生在手术室里意外发现了一种叫 RP-4560 的化合物能让病人"安静但不睡着"。十五年后，这个意外发现变成了现代精神药理学的起点。在 RCT 还没有被发明出来的年代，一个药怎么证明自己有效？这期拆解氯丙嗪的四层证据构建逻辑。
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CNS 药物 MI 视角深度拆解。每周从一片药入手，拆开它背后的证据体系——从 1952 年的氯丙嗪到 2024 年的 KarXT，120 年的精神科药物证据进化史。
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拆药笔记
1951 年，一个法国外科医生在手术室里意外发现了一种叫 RP-4560 的化合物能让病人"安静但不睡着"。十五年后，这个意外发现变成了现代精神药理学的起点。在 RCT 还没有被发明出来的年代，一个药怎么证明自己有效？这期拆解氯丙嗪的四层证据构建逻辑。
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