
NEET PG / FMG / INICET PODCAST BY MEDICO FOR MEDICOS
BIOCHEMISTRY - Krebs Cycle Rate-Limiting Step Vol 1 | NEET PG 2020 PYQ
High-Yield Daily Clinical Revision Podcast for NEET PG, FMGE, and INI-CET! Clinical Case Study: [Challenge Vol 1] A biochemistry researcher measures the rate of the Citric Acid Cycle under varying ATP levels. Which enzyme serves as the primary rate-limiting step of this pathway and is allosterically inhibited by high ATP? Options: β’ Option A: A. Isocitrate dehydrogenase β’ Option B: B. Citrate synthase β’ Option C: C. Alpha-ketoglutarate dehydrogenase β’ Option D: D. Malate dehydrogenase β Correct Answer: Option A Explanation: Isocitrate dehydrogenase is the rate-limiting enzyme of the citric acid cycle (Krebs cycle). It converts isocitrate to alpha-ketoglutarate, producing NADH and CO2, and is inhibited by ATP and NADH, but stimulated by ADP. (Volume 1 High-Yield Concept Review) Mnemonic: Krebs Cycle Rate Limiter V1 β’ Rate-limiting enzyme β Isocitrate Dehydrogenase β’ Inhibitors β ATP & NADH (signals high energy) β’ Activators β ADP & Ca2+ (signals energy demand) β οΈ Exam Trap to Avoid: Citrate synthase catalyzes the first reaction, but isocitrate dehydrogenase is the primary rate-limiting and regulated step. Follow Us & Prepare Smart: β’ Instagram: instagram.com/drstemcell_1 β’ Threads: threads.net/@drstemcell_1 β’ YouTube: youtube.com/@drstemcell-o2h β’ Facebook: facebook.com/drstemcell β’ Apple Podcasts: Apple Podcasts Link Join the discussion! Did you get this correct? Drop your option or score in the comments below! #NEETPG #FMGE #INICET #MBBS #DrStemCell #MedEd

