CReATe Podcast

ISRIB stands for “integrated stress response inhibitor). As we discuss here, it is an oral medication that inhibits an intracellular pathway called the integrative stress response pathway. It is not FDA approved for any...

Dr. Michael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and Executive Director of the ALS Center at the University of Miami. Here he discusses the recent publication “Proposed Research...

Here we have a podcast produced by artificial intelligence discussing the recent publication “Design considerations for C9orf72 disease prevention trials”.

The Wahls Protocol is a diet that may reduce inflammation, oxidative stress, and mitochondrial dysfunction. Although these are plausible mechanisms for slowing ALS progression, we discuss the fact that there are no...

Psilocybin is a psychedelic chemical derived from mushrooms. It is under study for mood problems in people with ALS. Here we review its plausible mechanisms for slowing ALS progression. But there are no data from...

Here we review ashwagandha a nutritional supplement that has plausible mechanisms for slowing ALS, promising pre-clinical evidence, and a reasonable safety profile. There is one person with ALS who experienced a...

Dr. Johnathan Cooper-Knock is a neurologist and clinical lecturer at the University of Sheffield. His research focuses on genetic causes of ALS. Here he discusses his recent publication “Extreme exercise in males is...

Here we review Zinc supplements as a treatment for ALS. These are inexpensive, reasonably safe at certain doses, and are easy to acquire. They have plausible mechanisms by which they could slow ALS progression. However...

Dr. Terry Heiman-Patterson is a neurologist and professor at Temple University and the director of the Center for Neurodegenerative Disorders and the MDA/ALS Center of Hope. Dr. Michael Benatar is a Professor of...

Dr. Ruben van Eijk is an associate professor in the Department of Neurology at the University Medical Center Utrecht in the Netherlands as well as a statistical consultant and medical statistician for the clinical trial...

Dr. Michael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and Executive Director of the ALS Center at the University of Miami. Here he discusses the recent publication “Prognostic clinical...

Dr. Jesse Crayle is a clinical neuromuscular fellow in the Department of Neurology at Washington University in St. Louis and Dr. Evadnie Rampersaud is a Principal Bioinformatics Research Scientist at St. Jude Children’s...

Nuedexta is a combination of dextromethorphan and quinidine, and is FDA approved for treating “pseudobulbar affect” (a symptom complex where patients lose control of their laughing and crying). Here we summarize recent...

Lions Mane is a mushroom that has neuroprotective, neurotrophic, antioxidant, and anti-inflammatory properties. Here we review what is known about its use in ALS models as well as patients living with the disease.

Insulin is a hormone most commonly used to lower blood sugar in people with diabetes. Here we talk about some theoretical ways it might help help people with ALS, as well as the lack of convincing case reports or trials...