Biohacking Autism with Nadia Elkhatib.
Autism Biology | The Blood Work I Wish I Had Checked First
Autism blood work rarely comes first. In this solo episode Nadia Elkhatib explains why she now starts with baseline biology before choosing the next specialty treatment for her son Jimmy. For twenty years she worked on Lyme, mold, gut, mast cells and detoxification, and that work helped. What she skipped was the foundation underneath it: thyroid function, sex hormones, insulin and metabolic health, the lipid panel, and nervous system regulation. Nadia walks through the difference between a laboratory reference range and the working targets her practitioners use, how a specialist's lens shapes the direction a family takes, and why anxiety, poor sleep, low motivation or withdrawal deserve a whole-body review rather than being filed under autism. She shares her own family's numbers, including the years when Jimmy's fasting glucose and insulin were drifting while his diet was already completely sugar free, and what changed once they measured instead of assumed. In this episode: Why normal is not the same as optimal How a specialist's lens shapes what gets treated first Why thyroid problems can look like behavior Why fasting glucose alone can miss the metabolic story Why caregiver health belongs in the same roadmap "The specialist cannot decide the entire order for us. That is our job as parents." NOTES ON WHAT YOU WILL HEAR IN THIS EPISODE Jimmy's history includes IVIG. That is one family's experience under medical care. IVIG has no FDA-approved indication for autism. Nadia describes tirzepatide being started with Jimmy's clinical team for a metabolic problem they had measured, and a HOMA-IR that moved from 3.34 to 1.56. Tirzepatide is approved for type 2 diabetes and for chronic weight management in qualifying adults. It is not approved for autism. This is one family's experience under clinical supervision. No doses and no sources are given anywhere in this episode. The optimal ranges Nadia refers to are the working targets she uses with her own practitioners. A HOMA-IR under 1 is her working target, not a laboratory reference range and not a consensus clinical guideline. Working targets vary by laboratory method, assay, age, treatment status and clinician. Reverse T3 is a test many integrative and functional practitioners use, and Dr. Amie Hornaman explains her reasoning in episode 25. Routine clinical guidelines generally do not recommend it for standard thyroid evaluation. Dr. Dayan Goodenowe is a guest on an upcoming episode of this podcast. He researches plasmalogens and also sells plasmalogen products. This episode discusses his published research only. RELATED EPISODES Episode 25 with Dr. Amie Hornaman, on thyroid: Episode 24 with Carole Petersen, on sex hormones: Episode 20, solo, on weight loss and metabolic health: Episode 10, solo, on anxiety: Episode 5, solo, on sleep: Episode 2, solo, on peptides and bioregulators: RESEARCH REFERENCED IN THIS EPISODE Sex hormones and autism Croonenberghs J, Van Grieken S, Wauters A, et al. Serum testosterone in male adolescents with autism. Neuro Endocrinol Lett. 2010;31(4):483-488. PMID 20802443. Thyroid and autism Desoky T, Hassan MH, Fayed HM, Sakhr HM. Biochemical assessments of thyroid profile, serum 25-hydroxycholecalciferol and cluster of differentiation 5 expression levels among children with autism. Neuropsychiatr Dis Treat. 2017;13:2397-2403. PMID 28979127. Cohen DJ, Young JG, Lowe TL, Harcherik D. Thyroid hormone in children with autism. J Autism Dev Disord. 1980;10(4):445-450. PMID 6927746. This older and larger study found no group difference, and is included for balance. Lipids and autism Kim EK, Neggers YH, Shin CS, Kim E, Kim EM. Lipid profiles in boys with autism. Nutr Res. 2010;30(4):255-260. PMID 20534328. Plasmalogens, autism and Alzheimer's disease Pastural E, Ritchie S, Lu Y, et al. Novel plasma phospholipid biomarkers of autism: mitochondrial dysfunction as a putative causative mechanism. Prostaglandins Leukot Essent Fatty Acids. 2009;81(4):253-264. PMID 19608392. Goodenowe DB, Cook LL, Liu J, et al. Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia. J Lipid Res. 2007;48(11):2485-2498. PMID 17664527. PEOPLE MENTIONED IN THIS EPISODE Hunter Williams Dr. Amie Hornaman Carole Petersen Nathalie Niddam Zora Benhamou Dr. Dayan Goodenowe Len Arcuri CONNECT WITH BIOHACKING AUTISM Website: biohackautism.com Email: nadia@biohackautism.com Instagram: @biohackautism TikTok: @biohackingautism YouTube: @BiohackingAutism LinkedIn: linkedin.com/in/nadiaelkhatib SUBSCRIBE If this episode helped you, please follow Biohacking Autism wherever you listen, and share it with a parent, caregiver, adult with autism or practitioner who might need to hear it. Sometimes one different question changes the entire direction of a family's care. ABOUT NADIA Nadia Elkhatib is the host of Biohacking Autism. She is not a physician. She is a mother who has spent more than twenty years learning from clinicians and researchers, collecting data, changing direction, and working to understand her son as a whole person. DISCLAIMER This episode describes one family's experience under clinical supervision and names prescription and hormone-related products that are not approved for autism. It is not medical advice and contains no doses, sources or treatment instructions. Please discuss any testing or treatment with a qualified clinician who knows the person's history. This podcast uses the following third-party services for analysis: OP3 - https://op3.dev/privacy