21 in 21

Haley Berkoe asks some of the biggest names in bitcoin and Silicon Valley 21 questions in 21 minutes, from the personalities you know and love to tech’s unsung heroes. A new episode drops when someone stops by Presidio Bitcoin. Reach out if you are or will be in the area and are interested in being on the show. presidiobitcoin.substack.com

21 in 21 is a technology podcast hosted by Hosted by Haley Berkoe, with 39 episodes on record and a Required Pod Score of 80. PitchCentric scores this show on Booking Probability, Listen Score, and live audience signals refreshed every 24 hours.

Hosted by Haley Berkoe hosts 21 in 21, a technology show with 39 episodes published.

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  21 in 21

  21 in 21: 0xSero on Local AI, Open Models, and Benchmarking

  Jul 28, 202621 min

  0xSero joins Haley Berkoe on 21 in 21 to discuss local AI, open models, and his soon-to-be-released platform for benchmarking open models and hardware ( local.ai ). He explains how his team benchmarks models and hardware, why local AI is becoming more capable and affordable, and why ownership and control matter as more people build their work around AI. They also discuss open-source AI culture, agentic payments, and what people can do to start experimenting with local models. FOLLOW: https://x.com/0xsero https://x.com/HBerkoe LINKS https://local.ai

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  21 in 21

  21 in 21: Bradley Axen on Buzz, goose, and AI at Block

  Jul 24, 202625 min

  Haley Berkoe sits down with Bradley Axen, who is leading many of Block's AI initiatives, including Buzz, a new open-source collaboration platform designed for humans and AI agents to work together. He also helped create goose, the open-source AI agent that was later donated to the Agentic AI Foundation under the Linux Foundation. They discuss how Block is using AI internally with tools like Builder Bot to help engineers navigate massive codebases, automate incident response, and collaborate more effectively. Brad also shares his thoughts on where open-source AI is headed, why model flexibility matters, and how new open source AI contributors can get involved. FOLLOW: https://x.com/bradleyaxen https://github.com/baxen https://x.com/HBerkoe LINKS: https://buzz.xyz https://goose-docs.ai TIMESTAMPS: 0:00 Introduction & Brad's journey into AI at Block 2:17 What goose is and why developers should care 3:15 Open models, local inference, and switching between providers 5:00 Do AI models perform better with their own coding harness? 6:40 Why enterprises benefit from model flexibility 8:25 Why AI inference is becoming critical infrastructure 9:16 How Block is approaching AI and open-source collaboration 10:25 Builder Bot: Block's internal AI assistant 13:50 Buzz: the future of collaborative AI workflows 15:47 Will Buzz replace Slack? 20:00 How AI is changing the role of engineers 21:45 Advice for getting started in open-source AI 24:22 Where to follow Brad's work

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  21 in 21

  21 in 21: Mic Neale on goose, Mesh LLM, and Open Source AI

  Jul 22, 202624 min

  Mic Neale, a member of the Spiral team at Block and a core developer of goose, an open source AI agent, joins Haley Berkoe on 21 in 21 to discuss goose, Mesh LLM, and open source AI. Mic shares how goose has evolved from a desktop app and CLI into the goose Development Kit (GDK), making it easier for developers to build AI applications. He also explains how Mesh LLM pools idle compute across devices, why local models and peer-to-peer infrastructure matter, and where he sees the overlap between bitcoin and open source AI. As a longtime open source contributor, Mic closes with advice for anyone looking to get involved in open source projects. FOLLOW: x.com/michaelneale x.com/HBerkoe LINKS goose-docs.ai meshllm.cloud spiral.xyz TIMESTAMPS 0:00 Intro & welcome 1:00 Mic's background 3:35 What makes the open-source AI community different? 5:02 What is goose? 6:55 Running AI models locally with goose 8:02 Why goose was designed differently from other AI agents 10:15 Mesh LLM and sharing unused compute across devices 13:20 Could you earn money by contributing inference? 17:05 Joining Spiral and the connection to bitcoin 19:11 The overlap between open-source AI and bitcoin 20:00 Career advice for aspiring open-source developers 22:00 Why open source still matters in the AI era 23:22 Where to find Mic online

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  21 in 21

  21 in 21: Patrick Ball on Using Bitcoin and AI to Defend Human Rights

  Jul 2, 202623 min

  Patrick Ball, Director of Research at the Human Rights Data Analysis Group, joins Haley Berkoe on 21 in 21 to discuss how data, bitcoin, and AI can help defend human rights. Patrick explains how his team uses statistics to document mass violence, how bitcoin can help protect the integrity of human rights evidence, and why nonprofits need decentralized tools and local AI to stay resilient. hrdag.org

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  21 in 21

  21 in 21: Calle on Cashu, Clawi, and AI Agents

  May 21, 202622 min

  On this episode of 21 in 21, Calle discusses his work on Cashu, Bitchat, and Clawi. He explores how AI agents could use bitcoin-native payments and why privacy-preserving infrastructure matters in an increasingly agentic internet. Calle also reflects on his journey down the bitcoin rabbit hole, from early work on Lightning infrastructure to building eCash systems, and shares his perspective on the evolution of AI agents. https://x.com/callebtc https://clawi.ai/ https://bitchat.free/ https://cashu.space/

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