Dr. GPCR Podcast

<p>Most receptors come with a history. Remulate came with a name — and almost nothing else. Dr. Beatriz Redondo, group leader at the University of Leipzig, has spent the last nine years building the first systematic...

<p>What if two nearly identical GPCRs make a worse chimera than two receptors from completely different classes? Charlotte Crauwels is building computational tools to find out why — and to predict which designs will...

<p>Every beta-2 agonist ever tested for muscle growth hits the same wall: desensitization. Dr. Tore Bengtsson built one that doesn't.</p><p>A professor at Stockholm University and founder of Atrogi, Dr. Bengtsson has...

<p>Dr. Joseph Kim solved cryo-EM structures of mu and kappa opioid receptors bound to the same small molecule — and found it does something different at each one.</p><p>In this conversation, Dr. Kim walks through his...

<p>How does ligand binding at the extracellular pocket of a GPCR reshape signaling on the intracellular side?</p><p>Biased agonism is often measured through pathway activation assays, but the structural origin of ligand...

<p>Conserved neuropeptide Y GPCRs orchestrate both feeding and mating behaviors in mosquitoes, with direct translational parallels to human gut-brain signaling.</p><p><br /></p><p>Quick Summary</p><p>Learn how receptor...

<p>Key Takeaways</p><p>How does the precise localization of GPCRs in lipid rafts reshape drug discovery strategy? Examine implications for functional assays and therapeutic innovation.</p><p>Explore the pivotal role of...

<p>Episode Summary</p><p><br></p><p>Potent in vitro hits often fail in vivo—Martin Marro details how robust assay choice and pathway deconvolution can revive GPCR drug discovery programs.</p><p>Listeners will learn...

<p>GPCR tools don’t move the field forward unless researchers can actually use them. This episode breaks down how collaboration turns probes into progress.</p><p>Summary</p><p><br>In the final episode of this series...

<p>Chemical probes are reshaping how we map GLP-1R in real time — revealing receptor pools antibodies can’t reliably capture.</p><p><br></p><p>This is Episode 2 of a 3-part GPCR tool-development series created in...

<p>Precise receptor mapping is reshaping how we understand incretin biology. David Hodson explains how GPCR-targeted chemical probes reveal where GLP-1 and GIP receptors actually signal across pancreas and brain—and...

<p>What makes Monash a model for modern pharmacology? Dr. Michelle Halls reveals how collaboration, mentorship, and receptor organization shape today’s GPCR breakthroughs — from femtomolar signaling to cancer biology. A...

<p>Predicting, not just explaining, can change how we design GPCR-targeted drugs. Jens Carlsson reveals how modeling bridges structure, function, and pharmacology.</p><p><br></p><p>Hear how predictive simulations shape...

<p>🔬 What if you could track GPCR internalization—no wash, high-throughput, and in endogenous systems?</p><p><br /></p><p>Discover how Dr. Eric Trinquet and Revvity built pH Sense, a next-gen fluorescence assay that...

<p>What if a failed med school plan led to a biotech breakthrough?<br>Ajay Yekkirala shares how GPCRs, AI, and scientific curiosity are reshaping pain therapeutics — and what it really takes to build better...