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Hosted by Dr. Yamina Berchiche · 🇺🇸 US · EN · 229 episodes
Established thought leaders with verified media credentials.
We bring you closer to dedicated scientists who work tirelessly to help understand GPCR pathophysiology.
Dr. Yamina Berchiche hosts Dr. GPCR Podcast, a science show with 229 episodes published.
Same binding affinity. Same target. One compound worked in vivo. The other did nothing. The answer was how long each molecule stayed on the CRF receptor — seven hours versus fifteen minutes — and no one had thought to me
Lefkowitz was told in 1973 that hormone receptors were a figment of his imagination. The work that proved otherwise became the molecular foundation of GPCR pharmacology. Nobel laureate Robert Lefkowitz traces the full ar
Most GPCR antibody failures are silent. The signal looks clean, the band is there, the experiment moves forward - until someone runs a knockout control and the signal is still there. Lin and Ball have spent years buildin
Most receptors come with a history. Remulate came with a name — and almost nothing else. Dr. Beatriz Redondo, group leader at the University of Leipzig, has spent the last nine years building the first systematic charact
What if two nearly identical GPCRs make a worse chimera than two receptors from completely different classes? Charlotte Crauwels is building computational tools to find out why — and to predict which designs will work be
Every beta-2 agonist ever tested for muscle growth hits the same wall: desensitization. Dr. Tore Bengtsson built one that doesn't. A professor at Stockholm University and founder of Atrogi, Dr. Bengtsson has spent 25 yea
Dr. Joseph Kim solved cryo-EM structures of mu and kappa opioid receptors bound to the same small molecule — and found it does something different at each one. In this conversation, Dr. Kim walks through his transition f
How does ligand binding at the extracellular pocket of a GPCR reshape signaling on the intracellular side? Biased agonism is often measured through pathway activation assays, but the structural origin of ligand bias rema
Conserved neuropeptide Y GPCRs orchestrate both feeding and mating behaviors in mosquitoes, with direct translational parallels to human gut-brain signaling. Quick Summary Learn how receptor internalization and neuropept
Key Takeaways How does the precise localization of GPCRs in lipid rafts reshape drug discovery strategy? Examine implications for functional assays and therapeutic innovation. Explore the pivotal role of GPCR-lipid raft
Episode Summary Potent in vitro hits often fail in vivo—Martin Marro details how robust assay choice and pathway deconvolution can revive GPCR drug discovery programs. Listeners will learn practical approaches to assay d
GPCR tools don’t move the field forward unless researchers can actually use them. This episode breaks down how collaboration turns probes into progress. Summary In the final episode of this series, David Hodson, Johannes
Chemical probes are reshaping how we map GLP-1R in real time — revealing receptor pools antibodies can’t reliably capture. This is Episode 2 of a 3-part GPCR tool-development series created in partnership with Celtarys R
Precise receptor mapping is reshaping how we understand incretin biology. David Hodson explains how GPCR-targeted chemical probes reveal where GLP-1 and GIP receptors actually signal across pancreas and brain—and what th
What makes Monash a model for modern pharmacology? Dr. Michelle Halls reveals how collaboration, mentorship, and receptor organization shape today’s GPCR breakthroughs — from femtomolar signaling to cancer biology. A loo
Predicting, not just explaining, can change how we design GPCR-targeted drugs. Jens Carlsson reveals how modeling bridges structure, function, and pharmacology. Hear how predictive simulations shape assay development, GP
🔬 What if you could track GPCR internalization—no wash, high-throughput, and in endogenous systems? Discover how Dr. Eric Trinquet and Revvity built pH Sense, a next-gen fluorescence assay that redefines receptor intern
What if a failed med school plan led to a biotech breakthrough? Ajay Yekkirala shares how GPCRs, AI, and scientific curiosity are reshaping pain therapeutics — and what it really takes to build better medicines. Watch th
When fentanyl slows your breath and xylazine traps it, the clock starts ticking. PhD candidate Catherine Demery takes us inside her fight to understand how fentanyl and xylazine shut down breathing in different ways—work
When fentanyl slows your breath and xylazine traps it, the clock starts ticking. PhD candidate Catherine Demery takes us inside her fight to understand how fentanyl and xylazine shut down breathing in different ways—work
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Dr. GPCR Podcast is hosted by Dr. Yamina Berchiche. The show is categorised under science (life) and has published 229 episodes.
Dr. GPCR Podcast has published 229 episodes.
Dr. GPCR Podcast regularly covers science, life. It sits in the science category, with a life focus.
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Episodes of Dr. GPCR Podcast average 56 minutes. a focused format where a clear narrative arc and tight preparation matter most.
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