What does Manifold do?

Manifold Bio is a biotechnology company based in Boston, founded in 2019. The company specializes in developing tissue-targeted biologics using its high-throughput in vivo discovery engine. This innovative platform combines AI-powered protein design, multiplexed in vivo screening, and molecular tracking technologies, enabling the testing of numerous protein candidates directly in living animals. Manifold Bio's mDesign platform allows for precise measurement of pharmacokinetics and tissue-specific delivery. The company focuses on creating medicines for various therapeutic areas, starting with brain delivery and expanding to peripheral tissues. Their mShuttle portfolio includes a library of optimized shuttles for targeted payload delivery. Manifold has established significant partnerships, including a $2 billion collaboration with Roche to develop brain shuttle technologies for neurological disorders. The company continues to grow and innovate in the healthcare and biotechnology sectors.